Humans Employ Simian Help to Fight HIV-1
"Rhesus monkey TRIM5α protects against HIV-1, but the only modern virus that the human protein has any effect on is one that causes leukemia in mice—which happens to be closely related to PtERV1."
We should harvest some TRIM5-alpha and cousin genes and insert it into trial MC's to defend them against HIV. I speculate that TRIM5-a would also help eliminate HIV from an infected patient.
If we cured HIV we could devote another ~15% of our healthcare resources to the next major health crisis, and use the data we've ggathered from fighting HIV to further work on proteinology and fighting other viruses and human bioengineering.
The gene could be introduced using a brief nonpathogenic viral or bacterial infection, or it could be manually introduced to marrow to produce 'coverage'.
How thoroughly does one need to blanket GM before a patient becomes successully modified? Temporary modification is insufficient, but may linger on for a time. Root cells must be modded if the process is to be pervasive and lasting. Can merely 40% of cells be tagged? Can they be spot tagged? Depending on the gene and purpose, yes, that is probable. Coverage from an effective vehicle vs stem cells or gels is likely the best choice for most situations.
We should harvest some TRIM5-alpha and cousin genes and insert it into trial MC's to defend them against HIV. I speculate that TRIM5-a would also help eliminate HIV from an infected patient.
If we cured HIV we could devote another ~15% of our healthcare resources to the next major health crisis, and use the data we've ggathered from fighting HIV to further work on proteinology and fighting other viruses and human bioengineering.
The gene could be introduced using a brief nonpathogenic viral or bacterial infection, or it could be manually introduced to marrow to produce 'coverage'.
How thoroughly does one need to blanket GM before a patient becomes successully modified? Temporary modification is insufficient, but may linger on for a time. Root cells must be modded if the process is to be pervasive and lasting. Can merely 40% of cells be tagged? Can they be spot tagged? Depending on the gene and purpose, yes, that is probable. Coverage from an effective vehicle vs stem cells or gels is likely the best choice for most situations.
posted by William Bunker at
1:22 PM
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